A number of cases were recored in Ireland in 2018 and further infections were reported in Northern Ireland in 2020.
The warning comes after Anderson Moores Veterinary Specialists in Winchester told about the two latest cases in Bristol and Kingston, Devon.
Since 2012 the animal hospital has been leading research into the Alabama Rot virus since 2012, and it is combining information on all confirmed cases and reports.
David Walker, who leads the team said: “We’re very sad to confirm two further cases of CRGV. Unfortunately, we find ourselves in the time of year when cases are most commonly identified.
“We’re advising dog owners across the country to remain calm but vigilant and to seek advice from their local vets if their dog develops unexplained skin lesions.”